Endocrine Abstracts

Type 2 diabetes (T2D), results from a deficiency in insulin action on peripheral tissues together with a lack of compensatory insulin production and release by pancreatic beta cells. The etiology of T2D involves both, genetic predisposition and environmental factors. Bisphenol-A (BPA) is a widespread endocrine disrupting chemical that modify pancreatic beta cell function and induce insulin resistance in rodents after treatment during different timing of exposure, including pre...

The estrogen receptors ERα and ERβ are currently considered important molecules in glucose and lipid metabolism, although their specific roles in pancreatic β-cells are still greatly unknown.The function of pancreatic β-cells is the biosynthesis and release of insulin, the only hormone able to decrease blood glucose levels. It has been recently described that ERα plays an essential role in the regulation of insulin biosynthesis b...